Expression and Activity of Collagenases in the Digital Laminae of Horses with Carbohydrate Overload-Induced Acute Laminitis

Impact of Laminitis on the Canonical Wnt Signaling Pathway in Basal Epithelial Cells of the Equine Digital Laminae

The digital laminae is a two layer tissue that attaches the distal phalanx to the inner hoof wall, thus suspending the horse's axial skeleton in the hoof capsule. This tissue fails at the epidermal:dermal junction in laminitic horses, causing crippling disease. Basal epithelial cells line the laminar epidermal:dermal junction, undergo physiological change in laminitic horses, and lose versican ...

Molecular Characterization of the Pathophysiology of the Digital Laminae in Acute Carbohydrate-Induced Equine Laminitis

Iron Status of Hyperinsulinemic/insulin Resistant Horses

Hyperinsulinemia unrelated to recent high soluble carbohydrate feeding and disproportionate to blood glucose levels, indicating insulin resistance, is well known to occur in equine pituitary pars intermedia dysfunction (PPID, Cushing's disease), has been described in ponies and miniatures, and is receiving increasing attention as an underlying problem in horses prone to obesity and laminitis. I...

Comparison of first and second acupuncture treatments in horses with chronic laminitis

Background: Laminitis is a common but critical disease that causes severe pain and disability in horses. The etiology and pathogenesis of laminitis remain inconclusive and a multimodal therapeutic approach is generally indicated. Acupuncture has been used as a treatment option; however, the required number of treatments is still controversial due to the lack of objective scient...

Production of amines in equine cecal contents in an in vitro model of carbohydrate overload.

Acute laminitis can be induced experimentally in horses by the administration of carbohydrate, resulting in fermentation within the cecum and ischemia-reperfusion of the digits. The products of fermentation that trigger acute laminitis are as yet unknown; however, compounds such as amines might play a role due to their potential vasoactive properties. The objectives of this study were to quanti...